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NXP2-antikroppar. TIF1γ-antikroppar. SRP-antikroppar. HMGCR-antikroppar. cN1A-antikroppar.

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HMGCR chr5. dHsaCP1000430. FAM. 65. Copy Number Determination.

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The HMGCR genetic variant might be associated with risks of prostate and breast cancers. HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase (human) HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene.

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Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary 1986-11-01 2021-03-06 2016-01-15 Gene: Hmgcr - ENSMUSG00000021670 - Mus musculus (mouse) The Function of HMGCR Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

The gene view histogram is a graphical view of mutations across HMGCR. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. The present work provides evidence to support the association of promoter DNA methylation status with the risk profile of CHD. Our data indicates that promoter DNA hypermethylation of the ABCG1 and GALNT2 genes, but not the HMGCR gene, is associated with an increased risk of CHD. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the p Search external sites for HMGCR Gene information about ENSG00000113161 / HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase We also investigated cancer risk for a SNP (rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment.
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HMGCR Gene Symbol Gene Info: Target Class Enzymes Target Subclass EC:1.1.1.34 Publications: HopkinsGroom: P04035. Version: 11-September-2012 Alternate Names: HMDH_HUMAN Uniprot Id HMGCR Uniprot Gene Name P04035 Uniprot Accession Gene … Gene; Hmgcr; Hmgcr. Addgene Alerts Receive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts.

Diseases associated with HMGCR include Familial  Species, TM, AA, Chromosomal Location, Gene Symbol, Gene Name, Reference. Human, 7, 888, 5q13.3, HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase  30 May 2010 Statins are a class of cholesterol lowering drugs that inhibit 3-hydroxy-3- methylglutaryl coenzyme A reductase (HMGCR), the enzyme which  24 Aug 2010 methylglutaryl coenzyme A reductase (HMGCR), is required for the generation genes and pathways in tumor development and progression. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is the key regulatory enzyme for cholesterol biosynthesis.
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Copy Number Determination. HMGCR chr5. dHsaCP1000430. FAM. 65.

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Antigen Sequence. Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. 12 Nov 2018 Early studies demonstrated that genetic deletion of HMGCR in mice 4 For instance, abundant sterols suppress hmgcr gene transcription,5  30 Nov 2018 muscle-specific HMGCR knockout mice also exhibited similar symptoms the Hmgcr gene in a concentration-dependent manner in primary  20 Mar 2018 Genetic variations at this locus have recently been linked with coronary heart disease. The association of HMGCR gene variants with mortality in  1 Dec 2016 Researchers have studied variants in the genes encoding HMGCR (the target of statins) and PCSK9 (the target of PCSK9 inhibitors) that affect  Buy HMGCR Inhibitors from Santa Cruz.

Alternate Names: 3156 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE HMGCR LDLCQ3 142910 5006 2012-09-18 · The gene encoding HMGCR uses alternative, mutually exclusive exon 1 sequences. This contributes to an increased complexity of HMGCR transcripts.